Passive Biotech Equities

First Trust NYSE Arca Biotechnology Index Fund

The First Trust NYSE® Arca® Biotechnology Index Fund (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the NYSE® Arca® Biotechnology Index (the “Index”).

$229.79

Key Metrics

TER 55.00% per year
Distribution policy Accumulating
Fund size USD 2,270 M
Inception date June 19, 2006
Holdings 32
Fund currency USD
Fund domicile US
Provider First Trust
For full official fund details, factsheets, and holdings, visit ftportfolios.com (opens in new tab).

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Historical Return

Last updated: Jun 15, 2026
1 Year +39.4%
3 Years (avg.) +12.2%
5 Years (avg.) +5.5%

Risk & Analysis Metrics

Last updated: Jun 15, 2026

Volatility

20.05% 1 Year
20.09% 3 Years
21.53% 5 Years
23.72% 10 Years

Max Drawdown

-14.26% 1 Year
-20.05% 3 Years
-29.95% 5 Years
-33.28% 10 Years

Sharpe Ratio

1.38 1 Year
0.43 3 Years
0.15 5 Years
0.32 10 Years

Return Triangle (Heatmap)

Last updated: Jun 15, 2026
2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025
2011 -17.1% 7.4% 18.7% 25.2% 22.1% 14.4% 17.2% 14.5% 15.1% 14.9% 13.1% 11.4% 10.7% 10.2% 11.1%
2012 39.2% 42.1% 43.7% 34.5% 22.0% 24.1% 19.9% 19.9% 19.2% 16.7% 14.5% 13.4% 12.7% 13.4%
2013 45.2% 46.0% 33.0% 18.1% 21.3% 17.0% 17.4% 16.9% 14.4% 12.2% 11.4% 10.7% 11.7%
2014 46.8% 27.3% 10.2% 16.0% 12.0% 13.3% 13.3% 11.0% 9.1% 8.4% 8.0% 9.3%
2015 10.3% -4.5% 7.3% 4.7% 7.6% 8.5% 6.7% 5.1% 4.8% 4.7% 6.4%
2016 -17.3% 5.8% 2.9% 6.9% 8.2% 6.1% 4.4% 4.2% 4.1% 6.0%
2017 35.3% 14.8% 16.5% 15.7% 11.5% 8.5% 7.7% 7.2% 8.9%
2018 -2.5% 8.1% 9.8% 6.3% 3.8% 3.7% 3.7% 6.0%
2019 19.9% 16.6% 9.4% 5.5% 5.0% 4.8% 7.3%
2020 13.3% 4.5% 1.1% 1.5% 2.0% 5.3%
2021 -3.6% -4.6% -2.1% -0.7% 3.8%
2022 -5.5% -1.4% 0.3% 5.8%
2023 2.9% 3.3% 9.8%
2024 3.7% 13.4%
2025 24.0%

Distributions

*by ETF Portfolio Weight Last updated: Jun 15, 2026

Profit Margin Distribution

< 0%
21%
1y 3y N/A N/A
0 - 5%
0%
1y 3y N/A N/A
5 - 10%
20%
1y 3y N/A N/A
10 - 15%
9%
1y 3y N/A N/A
15 - 20%
6%
1y 3y N/A N/A
20 - 30%
17%
1y 3y N/A N/A
30 - 40%
18%
1y 3y N/A N/A
> 40%
8%
1y 3y N/A N/A

P/E Ratio Distribution

< 0
18%
1y 3y N/A N/A
0 - 10
3%
1y 3y N/A N/A
10 - 15
4%
1y 3y N/A N/A
15 - 20
18%
1y 3y N/A N/A
20 - 25
18%
1y 3y N/A N/A
25 - 35
7%
1y 3y N/A N/A
35 - 50
18%
1y 3y N/A N/A
> 50
16%
1y 3y N/A N/A

Discounted Cash Flow

Weighted Average Undervaluation
N/A
Undervalued
> 60%
0%
1y 3y N/A N/A
45 - 60%
0%
1y 3y N/A N/A
30 - 45%
0%
1y 3y N/A N/A
15 - 30%
0%
1y 3y N/A N/A
Fair (&plusmn;15%)
0%
1y 3y N/A N/A
Overvalued
15 - 30%
0%
1y 3y N/A N/A
30 - 45%
0%
1y 3y N/A N/A
45 - 60%
0%
1y 3y N/A N/A
> 60%
0%
1y 3y N/A N/A

Market Cap Size Distribution

Micro Cap
2.0%
1y 3y N/A N/A
Small Cap
3.2%
1y 3y N/A N/A
Mid Cap
28.1%
1y 3y N/A N/A
Large Cap
66.7%
1y 3y N/A N/A
Mega Cap
0.0%
1y 3y N/A N/A
Micro: < $300M Small: $300M–$2B Mid: $2B–$10B Large: $10B–$200B Mega: > $200B

Portfolio Concentration

*by ETF Portfolio Weight Last updated: Jun 15, 2026
21.8% Top 5 Holdings
39.9% Top 10 Holdings
100.0% Top 50 Holdings
100.0% Top 100 Holdings
Top 5 Companies
MRNA Moderna Inc
5.3%
UTHR United Therapeutics Corp
4.4%
ALKS Alkermes plc
4.2%
GILD Gilead Sciences, Inc.
4.1%
AXSM Axsome Therapeutics Inc
3.9%

Latest News

4 months ago • reuters.com

Moderna rises as up to $2.25 billion settlement for COVID vaccine patent dispute to remove overhang

Moderna shares rose 10% in premarket trading on Wednesday after the company settled a long-running legal battle over the technology that made ​its ...

4 months ago • benzinga.com

Moderna's $950 Million Settlement Clears Legal Overhang, Stock Soars

Moderna Inc. (NASDAQ: MRNA) shares are up during Wednesday's premarket session following a settlement agreement with Arbutus Biopharma Corporation ...

4 months ago • barrons.com

Moderna Stock Rallies. This Big Risk Just Got Eliminated.

The company settles to resove patent litigation related to its Covid-19 vaccine, removing an overhang for shares.

Average metrics of all companies in portfolio

Last updated: Jun 21, 2026
Market
Average
Market Cap The market value of the company. It's calculated by multiplying the share price by the number of outstanding shares. $34.6B -
Dividend Yield Yearly payout to shareholders per share. The percentage indicates the payout in relation to the share price. 0.26% 2.03%
Beta Indicates the relationship between the price performance of a share and the market. 0.67 -
P/E Ratio Ratio between share price and earnings per share. A low ratio could indicate that the stock is undervalued or investors aren't expecting high growth. A high ratio could indicate that the stock is overvalued or investors are expecting high growth. 43.24 28.29
Negative P/E Ratio a negative P/E ratio shows that the company is not profitable, and it shows how many years it would take the company to lose its entire market capitalisation if it did not change anything -49.14 -
Profitable Companies 83% -
PEG The ratio between the P/E ratio and the growth rate of the company's earnings per share in the last twelve months. A lower PEG could mean that a stock is undervalued. 32.03 14.56
Price to Sales Ratio Market cap divided by the revenue in the most recent year. 7.59 8.28
Price to Book Ratio Price to Book Ratio is the Market cap divided by the Book value of the company 8.88 10.72
Market
Average
Enterprise Value to EBIT Enterprise Value divided by EBIT 12.44 21.15
Enterprise Value to Revenue Enterprise value divided by revenue 7.1 8.72
Total Debt to Enterprise Value Total debt divided by enterprise value 0.08 0.05
Debt to Equity A higher ratio indicates a higher risk. However, the ratio is difficult to compare between industries where common amounts of debt vary. 0.69 0.33
Profit Margin Net income divided by revenue of the last 4 quarters. It indicates the company's profitability. 7.33% -6.18%
Quarterly Earnings Growth (YoY) The rate at which the company's net income has increased to the same quarter one year ago. -25.3% -117.9%
Return on Equity Equity divided by market cap. 19.97% 1.23%
Return on Assets Indicates a company's profitability in relation to its total assets. 6.34% 3.29%
Return on Invested Capital Return on invested capital (ROIC) is net income after dividends divided by the sum of debt and equity. It shows how effective a company is at turning capital invested by shareholders and other debtholders into profits. 7.42% 3.31%

Sectors

Manufacturing 82.9%
Professional, Scientific, and Technical Services 11.4%
Health Care and Social Assistance 5.8%
Other 0.0%

Countries

United States 84.8%
Ireland 3.9%
Netherlands 3.3%
Germany 2.8%
Denmark 2.6%
Switzerland 2.5%
Other 0.0%

Stock Screener

Select filters to narrow down the 30 investments below

30 companies

Limit holdings to companies in a single sector.

$0B >$1T

Ratio between share price and earnings per share. A low ratio could indicate undervaluation.

<0 >50

Ratio of dividends in the last 12 months to current share price.

0% 3%

Revenue increase compared to the same quarter one year ago.

0% 30%

Net income increase compared to the same quarter one year ago.

0% 30%

Profitability of the last quarter.

<-30% >30%

A higher ratio indicates a higher risk. The ratio is difficult to compare between industries.

<0 >3

Discounted cash flow valuation vs. current price. Positive = undervalued, negative = overvalued.

<-50% >+100%
Market Cap $25.38B
P/E Ratio -7.9
Dividends 0.0%
Total Investment $119.45M
Weight 5.26%

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Market Cap $22.78B
P/E Ratio 18.1
Dividends 0.0%
Total Investment $98.94M
Weight 4.36%

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Market Cap $7.5B
P/E Ratio 48.4
Dividends 0.0%
Total Investment $96.15M
Weight 4.24%

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Market Cap $153.66B
P/E Ratio 16.7
Dividends 2.6%
Total Investment $92.82M
Weight 4.09%

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Market Cap $12.89B
P/E Ratio -67.2
Dividends 0.0%
Total Investment $88.21M
Weight 3.89%

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Market Cap $182.21B
P/E Ratio 23.3
Dividends 2.9%
Total Investment $87.01M
Weight 3.83%

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Market Cap $8.58B
P/E Ratio 177.6
Dividends 0.0%
Total Investment $86.69M
Weight 3.82%

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Market Cap $10.26B
P/E Ratio 45.3
Dividends 0.0%
Total Investment $79.69M
Weight 3.51%

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Market Cap $29.02B
P/E Ratio 21.0
Dividends 0.0%
Total Investment $78.8M
Weight 3.47%

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Market Cap $15.92B
P/E Ratio 23.8
Dividends 0.0%
Total Investment $78.24M
Weight 3.45%

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Market Cap $62.84B
P/E Ratio 14.3
Dividends 0.6%
Total Investment $78.23M
Weight 3.45%

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Market Cap $114.63B
P/E Ratio 26.5
Dividends 0.0%
Total Investment $77.62M
Weight 3.42%

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Market Cap $54.32B
P/E Ratio 49.7
Dividends 0.0%
Total Investment $74.72M
Weight 3.29%

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Market Cap $1.85B
P/E Ratio 28.3
Dividends 0.0%
Total Investment $73.64M
Weight 3.24%

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Market Cap $8.13B
P/E Ratio 23.5
Dividends 0.0%
Total Investment $71.92M
Weight 3.17%

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Market Cap $22.98B
P/E Ratio -15.7
Dividends 0.0%
Total Investment $71.79M
Weight 3.16%

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Market Cap $20.21B
P/E Ratio 4.0
Dividends 0.0%
Total Investment $70.88M
Weight 3.12%

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