Spyre Therapeutics Inc.

Spyre Therapeutics Inc.

SYRE

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Market Cap$4.44B
Close$

Compare to Similar Companies

P/E RatioDividendsReturn on EquityPrice-to-SalesDebt-to-Equity
Spyre Therapeutics Inc.Spyre Therapeutics Inc.-141.7--27%--
$88.64

Target Price by Analysts

20.6% upsideSpyre Therapeutics Target Price DetailsTarget Price
$0.25

Current Fair Value

99.7% downside

Overvalued by 99.7% based on the discounted cash flow analysis.

Share Statistics

Market cap$4.44 Billion
Enterprise Value$4.34 Billion
Dividend Yield$- (-)
Earnings per Share$-1.98
Beta3.13
Outstanding Shares346,045,000

Return

Return on Equity-26.75%ROE
Return on Assets-23.49%
Return on Invested Capital-28.94%

Valuation & Multiples

P/E Ratio-141.75P/E Ratio
PEG-261.9PEG
Price to Sales-Price to Sales
Price to Book Ratio73.52Price to Book Ratio
Enterprise Value to Revenue47.98
Enterprise Value to EBIT-22.11
Enterprise Value to Net Income-25
Total Debt to Enterprise0
Debt to Equity0Debt to Equity

Revenue Sources

No data

Insider Trades

Last Earnings Call

Report Date
May 14, 2026
EPS Estimate
$-0.66
Average shareholder expectation
Revenue Estimate
$70.87 M
Average shareholder expectation

Next Earnings Call

Expected Date
August 4, 2026
EPS Estimate
$-0.70
Average shareholder expectation
Revenue Estimate
-
Average shareholder expectation

Institutional Put/Call Ratio

Market sentiment based on institutional option activity.

Put/Call Ratio0.0876 0.86%
Total Calls324,200 21.67%
Total Puts28,400 13.15%

Institutional Ownership

Holdings and activity of institutional investors.

Ownership %23.88% 84.19%
Total Invested$4.16B 56.93%
Investors Holding200 44.00%

ESG Score

No data

About Spyre Therapeutics Inc.

83 employees

aeglea was founded in december of 2013 to develop engineered human enzymes invented in the laboratory of george georgiou, ph.d. of the university of texas at austin. the convergence of discovery and technology has created a significant...