iShares Neuroscience and Healthcare ETF (IBRN)

Key Metrics

TER 0.47% per year

Distribution policy Distributing

Fund size USD 5 M

Inception date August 24, 2022

Holdings 84

Fund currency USD

Fund domicile US

Provider iShares

For full official fund details, factsheets, and holdings, visit ishares.com (opens in new tab).

Historical Return

Last updated: Jul 01, 2026

1 Year +74.8% +0.8% Div

3 Years (avg.) +17.3% +0.8% Div

5 Years (avg.) +9.6% +0.8% Div

Risk & Analysis Metrics

Last updated: Jul 01, 2026

Volatility

25.60% 1 Year

24.74% 3 Years

25.13% 5 Years

25.13% 10 Years

Max Drawdown

-8.73% 1 Year

-35.85% 3 Years

-35.85% 5 Years

-35.85% 10 Years

Sharpe Ratio

1.92 1 Year

0.56 3 Years

0.41 5 Years

0.41 10 Years

Return Triangle (Heatmap)

Last updated: Jul 01, 2026

	2022	2023	2024	2025
2022	5.8%	4.3%	2.8%	7.7%
2023		2.8%	1.3%	8.3%
2024			-0.1%	11.2%
2025				23.7%

Distributions

*by ETF Portfolio Weight Last updated: Jul 01, 2026

Profit Margin Distribution

< 0%

53%

1y 3y N/A N/A

0 - 5%

1y 3y N/A N/A

5 - 10%

1y 3y N/A N/A

10 - 15%

17%

1y 3y N/A N/A

15 - 20%

1y 3y N/A N/A

20 - 30%

1y 3y N/A N/A

30 - 40%

31%

1y 3y N/A N/A

> 40%

1y 3y N/A N/A

P/E Ratio Distribution

< 0

73%

1y 3y N/A N/A

0 - 10

1y 3y N/A N/A

10 - 15

1y 3y N/A N/A

15 - 20

1y 3y N/A N/A

20 - 25

1y 3y N/A N/A

25 - 35

1y 3y N/A N/A

35 - 50

1y 3y N/A N/A

> 50

1y 3y N/A N/A

Discounted Cash Flow

Weighted Average Undervaluation

N/A

Undervalued

> 60%

1y 3y N/A N/A

45 - 60%

1y 3y N/A N/A

30 - 45%

1y 3y N/A N/A

15 - 30%

1y 3y N/A N/A

Fair (±15%)

1y 3y N/A N/A

Overvalued

15 - 30%

1y 3y N/A N/A

30 - 45%

1y 3y N/A N/A

45 - 60%

1y 3y N/A N/A

> 60%

1y 3y N/A N/A

Market Cap Size Distribution

Micro Cap

3.3%

1y 3y N/A N/A

Small Cap

22.5%

1y 3y N/A N/A

Mid Cap

59.7%

1y 3y N/A N/A

Large Cap

14.5%

1y 3y N/A N/A

Mega Cap

0.0%

1y 3y N/A N/A

Micro: < $300M Small: $300M–$2B Mid: $2B–$10B Large: $10B–$200B Mega: > $200B

Average metrics of all companies in portfolio

Last updated: Jun 28, 2026

Market
Average

Market Cap The market value of the company. It's calculated by multiplying the share price by the number of outstanding shares.	$9.84B	-
Dividend Yield Yearly payout to shareholders per share. The percentage indicates the payout in relation to the share price.	0.00%	2.01%
Beta Indicates the relationship between the price performance of a share and the market.	0.9	-
P/E Ratio Ratio between share price and earnings per share. A low ratio could indicate that the stock is undervalued or investors aren't expecting high growth. A high ratio could indicate that the stock is overvalued or investors are expecting high growth.	29.65	28.61
Negative P/E Ratio a negative P/E ratio shows that the company is not profitable, and it shows how many years it would take the company to lose its entire market capitalisation if it did not change anything	-16.61	-
Profitable Companies	28%	-
PEG The ratio between the P/E ratio and the growth rate of the company's earnings per share in the last twelve months. A lower PEG could mean that a stock is undervalued.	23.26	18.04
Price to Sales Ratio Market cap divided by the revenue in the most recent year.	6.62	8.09
Price to Book Ratio Price to Book Ratio is the Market cap divided by the Book value of the company	4.23	10.18

Market
Average

Enterprise Value to EBIT Enterprise Value divided by EBIT	-9.92	20.33
Enterprise Value to Revenue Enterprise value divided by revenue	9.02	7.98
Total Debt to Enterprise Value Total debt divided by enterprise value	0.06	0.04
Debt to Equity A higher ratio indicates a higher risk. However, the ratio is difficult to compare between industries where common amounts of debt vary.	0.1	0.27
Profit Margin Net income divided by revenue of the last 4 quarters. It indicates the company's profitability.	13.25%	20.81%
Quarterly Earnings Growth (YoY) The rate at which the company's net income has increased to the same quarter one year ago.	+6.2%	-118.0%
Return on Equity Equity divided by market cap.	-19.15%	2.67%
Return on Assets Indicates a company's profitability in relation to its total assets.	-20.64%	4.17%
Return on Invested Capital Return on invested capital (ROIC) is net income after dividends divided by the sum of debt and equity. It shows how effective a company is at turning capital invested by shareholders and other debtholders into profits.	-24.04%	3.72%

Sectors

Manufacturing	46.8%
Professional, Scientific, and Technical Services	7.6%
Healthcare	1.1%
Health Technology	0.6%
Other	43.9%

Countries

United States	74.9%
Ireland	5.1%
Canada	4.2%
Netherlands	3.8%
South Korea	2.4%
Sweden	2.0%
Denmark	1.8%
Switzerland	1.5%
China	1.0%
Australia	1.0%
Japan	0.8%
France	0.7%
Israel	0.4%
Other	0.4%
Italy	0.3%

Limit holdings to companies in a single sector.

$0B >$1T

Ratio between share price and earnings per share. A low ratio could indicate undervaluation.

<0 >50

Ratio of dividends in the last 12 months to current share price.

0% 3%

Revenue increase compared to the same quarter one year ago.

0% 30%

Net income increase compared to the same quarter one year ago.

0% 30%

Profitability of the last quarter.

<-30% >30%

A higher ratio indicates a higher risk. The ratio is difficult to compare between industries.

<0 >3

Discounted cash flow valuation vs. current price. Positive = undervalued, negative = overvalued.

<-50% >+100%

Market Cap

P/E Ratio

Total Investment

Weight

Xenon Pharmaceuticals Inc

XENE - Manufacturing

Market Cap $4.72B

P/E Ratio -12.7

Dividends 0.0%

Total Investment $247.64K

Weight 4.79%

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Arrowhead Pharmaceuticals Inc.

ARWR - Manufacturing

Market Cap $11.11B

P/E Ratio -36.9

Dividends 0.0%

Total Investment $228.01K

Weight 4.41%

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Argen X SE - ADR

ARGX - Manufacturing

Market Cap $54.9B

P/E Ratio 50.1

Dividends 0.0%

Total Investment $200.9K

Weight 3.88%

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PTC Therapeutics Inc

PTCT - Manufacturing

Market Cap $7B

P/E Ratio -36.2

Dividends 0.0%

Total Investment $191.15K

Weight 3.69%

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Biogen Inc

BIIB - Manufacturing

Market Cap $31.89B

P/E Ratio 23.1

Dividends 0.0%

Total Investment $190.04K

Weight 3.67%

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Scholar Rock Holding Corp

SRRK - Professional, Scientific, and Technical Services

Market Cap $6.56B

P/E Ratio -15.9

Dividends 0.0%

Total Investment $189.94K

Weight 3.67%

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Praxis Precision Medicines Inc

PRAX - Manufacturing

Market Cap $6.93B

P/E Ratio -24.5

Dividends 0.0%

Total Investment $189.39K

Weight 3.66%

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Dianthus Therapeutics Inc

DNTH - Professional, Scientific, and Technical Services

Market Cap $3.98B

P/E Ratio -866.8

Dividends 0.0%

Total Investment $175.42K

Weight 3.39%

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Catalyst Pharmaceuticals Inc

CPRX - Manufacturing

Market Cap $3.86B

P/E Ratio 17.5

Dividends 0.0%

Total Investment $170.13K

Weight 3.29%

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Denali Therapeutics Inc

DNLI - Manufacturing

Market Cap $4.06B

P/E Ratio -8.9

Dividends 0.0%

Total Investment $146.02K

Weight 2.82%

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Edgewise Therapeutics Inc

EWTX - Manufacturing

Market Cap $4.46B

P/E Ratio -25.0

Dividends 0.0%

Total Investment $131.02K

Weight 2.53%

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Dyne Therapeutics Inc

DYN - Manufacturing

Market Cap $3.46B

P/E Ratio -6.5

Dividends 0.0%

Total Investment $122.25K

Weight 2.36%

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Sarepta Therapeutics Inc

SRPT - Manufacturing

Market Cap $1.78B

P/E Ratio 27.2

Dividends 0.0%

Total Investment $114.42K

Weight 2.21%

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Capricor Therapeutics Inc

CAPR - Manufacturing

Market Cap $1.21B

P/E Ratio -11.4

Dividends 0.0%

Total Investment $90.43K

Weight 1.75%

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Taysha Gene Therapies Inc

TSHA - Manufacturing

Market Cap $1.59B

P/E Ratio -16.6

Dividends 0.0%

Total Investment $79.04K

Weight 1.53%

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Biohaven Ltd

BHVN - Manufacturing

Market Cap $1.68B

P/E Ratio -2.8

Dividends 0.0%

Total Investment $67.28K

Weight 1.30%

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Rapport Therapeutics Inc.

RAPP

Market Cap $1.46B

P/E Ratio -15.4

Dividends 0.0%

Total Investment $53.34K

Weight 1.03%

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Bright Minds Biosciences Inc

DRUG - Manufacturing

Market Cap $510.63M

P/E Ratio -26.4

Dividends 0.0%

Total Investment $47.41K

Weight 0.92%

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Annexon Inc

ANNX - Manufacturing

Market Cap $655.38M

P/E Ratio -4.5

Dividends 0.0%

Total Investment $41.37K

Weight 0.80%

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Alto Neuroscience Inc.

ANRO

Market Cap $948.94M

P/E Ratio -10.9

Dividends 0.0%

Total Investment $40.31K

Weight 0.78%

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Key Metrics

Compare similar ETFs

Historical Return

Risk & Analysis Metrics

Volatility

Max Drawdown

Sharpe Ratio

Return Triangle (Heatmap)

Distributions

Profit Margin Distribution

P/E Ratio Distribution

Discounted Cash Flow

Market Cap Size Distribution

Portfolio Concentration

Latest News

Denali Therapeutics (DNLI) Stock Jumps 9.7%: Will It Continue to Soar?

Levi & Korsinsky Notifies Biogen Inc. Investors of a Class Action Lawsuit and Upcoming Deadline - BIIB

The Schall Law Firm Invites Shareholders In Biogen Inc Who Incurred Losses To Initiate Dialogue Please Be Aware Of The Deadline In This Matter

Average metrics of all companies in portfolio

Sectors

Countries

Stock Screener

Xenon Pharmaceuticals Inc

Xenon Pharmaceuticals Inc

Arrowhead Pharmaceuticals Inc.

Arrowhead Pharmaceuticals Inc.

Argen X SE - ADR

Argen X SE - ADR

PTC Therapeutics Inc

PTC Therapeutics Inc

Biogen Inc

Biogen Inc

Scholar Rock Holding Corp

Scholar Rock Holding Corp

Praxis Precision Medicines Inc

Praxis Precision Medicines Inc

Dianthus Therapeutics Inc

Dianthus Therapeutics Inc

Catalyst Pharmaceuticals Inc

Catalyst Pharmaceuticals Inc

Denali Therapeutics Inc

Denali Therapeutics Inc

Edgewise Therapeutics Inc

Edgewise Therapeutics Inc

Dyne Therapeutics Inc

Dyne Therapeutics Inc

Sarepta Therapeutics Inc

Sarepta Therapeutics Inc

Capricor Therapeutics Inc

Capricor Therapeutics Inc

Taysha Gene Therapies Inc

Taysha Gene Therapies Inc

Biohaven Ltd

Biohaven Ltd

Rapport Therapeutics Inc.

Rapport Therapeutics Inc.

Bright Minds Biosciences Inc

Bright Minds Biosciences Inc

Annexon Inc

Annexon Inc

Alto Neuroscience Inc.

Alto Neuroscience Inc.

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