Ionis Pharmaceuticals Inc

Ionis Pharmaceuticals Inc

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Market Cap$12.64B
Close$

Compare to Similar Companies

P/E RatioDividendsReturn on EquityPrice-to-SalesDebt-to-Equity
Ionis Pharmaceuticals IncIonis Pharmaceuticals Inc-38.6--50%0.14.3
$108.89

Target Price by Analysts

47.5% upsideIonis Pharmaceuticals Target Price DetailsTarget Price
$-57.64

Current Fair Value

178.1% downside

Overvalued by 178.1% based on the discounted cash flow analysis.

Share Statistics

Market cap$12.64 Billion
Enterprise Value$14.58 Billion
Dividend Yield$- (-)
Earnings per Share$-2.38
Beta0.38
Outstanding Shares164,874,000

Return

Return on Equity-49.67%ROE
Return on Assets-7.07%
Return on Invested Capital-5376.75%

Valuation & Multiples

P/E Ratio-38.62P/E Ratio
PEG104.3PEG
Price to Sales0.09Price to Sales
Price to Book Ratio36.91Price to Book Ratio
Enterprise Value to Revenue0.11
Enterprise Value to EBIT-0.1
Enterprise Value to Net Income-60
Total Debt to Enterprise0.14
Debt to Equity4.3Debt to Equity

Revenue Sources

No data

Insider Trades

Last Earnings Call

Report Date
May 6, 2026
EPS Estimate
$-0.77
Average shareholder expectation
Revenue Estimate
$198.93 M
Average shareholder expectation

Next Earnings Call

Expected Date
July 29, 2026
EPS Estimate
$-1.03
Average shareholder expectation
Revenue Estimate
$195.54 M
Average shareholder expectation

Institutional Put/Call Ratio

Market sentiment based on institutional option activity.

Put/Call Ratio1.0228 35.48%
Total Calls1,620,754 6.90%
Total Puts1,657,700 42.55%

Institutional Ownership

Holdings and activity of institutional investors.

Ownership %107.83% 1.93%
Total Invested$12.96B 3.75%
Investors Holding520 8.00%

ESG Score

No data

About Ionis Pharmaceuticals Inc

817 employees
CEO: Brett Monia

Ionis Pharmaceuticals is a biotechnology company based in Carlsbad, California that specializes in discovering and developing RNA-targeted therapeutics. The company has 3 commercially approved medicines: Spinraza , Tegsedi , and WAYLIVRA...

Relevant Senate Committees

Joint Committee on Taxation

This committee directly influences corporate tax structures and capital investment credits through its analysis and scoring of tax legislation, which critically impacts Ionis Pharmaceuticals' financial performance.

Finance

This powerful committee controls taxation (influencing corporate valuations), trade, and entitlement spending (e.g., Medicare pricing), all of which directly affect Ionis Pharmaceuticals' profitability and market access for its drugs.

Appropriations

This committee allocates federal discretionary spending, directly influencing funding for scientific research (e.g., NIH) and healthcare programs that impact drug reimbursement and the R&D ecosystem.

Health, Education, Labor, and Pensions

This committee directly regulates the FDA (drug approval process) and the NIH (biomedical research funding), both of which are central to Ionis Pharmaceuticals' operations and success.

Judiciary

This committee oversees intellectual property laws (patents), which are critical for protecting pharmaceutical innovations, and antitrust laws, impacting potential mergers and market practices.