John Paulson acquired 1.34M Madrigal Pharmaceuticals shares worth $712M. That's 28.25% of their entire equity portfolio (2nd largest holding). The investor owns 5.80% of the outstanding Madrigal Pharmaceuticals stock. John Paulson started to build up the position in Madrigal Pharmaceuticals in Q2 2023 and continued to invest until Q1 2025. Since then they sold 760k shares. The stake costed the investor $302M, netting the investor a gain of 136% so far.