Jim Simons's position in Vertex Pharmaceuticals is currently worth $190M. That's 0.27% of their equity portfolio (65th largest holding). The first Vertex Pharmaceuticals trade was made in Q3 2013. Since then Jim Simons bought shares 21 more times and sold shares on 25 occasions. The stake costed the investor $78.8M, netting the investor a gain of 141% so far.