Jim Simons's position in Vertex Pharmaceuticals is currently worth $538 Million. That's 0.76% of their equity portfolio (11th largest holding). The first Vertex Pharmaceuticals trade was made in Q3 2013. Since then Jim Simons bought shares 21 more times and sold shares on 21 occasions. The stake costed the investor $219 Million, netting the investor a gain of 146% so far.