Jim Simons's position in Vertex Pharmaceuticals is currently worth $176M. That's 0.24% of their equity portfolio (75th largest holding). The first Vertex Pharmaceuticals trade was made in Q3 2013. Since then Jim Simons bought shares 21 more times and sold shares on 26 occasions. The stake costed the investor $59.8M, netting the investor a gain of 194% so far.