Jim Simons's position in Vertex Pharmaceuticals is currently worth $754 Million. That's 1.09% of their equity portfolio (5th largest holding). The first Vertex Pharmaceuticals trade was made in Q3 2013. Since then Jim Simons bought shares 21 more times and sold shares on nineteen occasions. The stake costed the investor $305 Million, netting the investor a gain of 147% so far.