Jim Simons's position in United Therapeutics is currently worth $644 Million. That's 0.99% of their equity portfolio (6th largest holding). The investor owns 4.86% of the outstanding United Therapeutics stock. The first United Therapeutics trade was made in Q2 2013. Since then Jim Simons bought shares 23 more times and sold shares on 23 occasions. The stake costed the investor $243 Million, netting the investor a gain of 165% so far.