Jim Simons's position in United Therapeutics is currently worth $979M. That's 1.35% of their equity portfolio (4th largest holding). The investor owns 4.14% of the outstanding United Therapeutics stock. The first United Therapeutics trade was made in Q2 2013. Since then Jim Simons bought shares 26 more times and sold shares on 25 occasions. The stake costed the investor $214M, netting the investor a gain of 357% so far.