Jim Simons's position in United Therapeutics is currently worth $490 Million. That's 0.75% of their equity portfolio (11th largest holding). The investor owns 4.67% of the outstanding United Therapeutics stock. The first United Therapeutics trade was made in Q2 2013. Since then Jim Simons bought shares 21 more times and sold shares on nineteen occasions. The stake costed the investor $250 Million, netting the investor a gain of 96% so far.