Jim Simons acquired 451 Thousand Sage Therapeutics shares worth $2.96 Million. That's 0.00% of their equity portfolio (1590th largest holding). The first Sage Therapeutics trade was made in Q1 2015. Since then Jim Simons bought shares eight more times and sold shares on eleven occasions. The investor's estimated purchase price is $6.07 Million, resulting in a loss of 51%.