Jim Simons acquired 15.3 Million Novo Nordisk - ADR shares worth $1.92 Billion. It makes up 2.47% of their stock portfolio and is their biggest holding. The first Novo Nordisk - ADR trade was made in Q2 2013. Since then Jim Simons bought shares nineteen more times and sold shares on eighteen occasions. The stake costed the investor $695 Million, netting the investor a gain of 176% so far.