Jim Simons acquired 13.8 Million Novo Nordisk - ADR shares worth $1.77 Billion. It makes up 2.59% of their stock portfolio and is their biggest holding. The first Novo Nordisk - ADR trade was made in Q2 2013. Since then Jim Simons bought shares nineteen more times and sold shares on 23 occasions. The stake costed the investor $629 Million, netting the investor a gain of 182% so far.