Jim Simons acquired 10.8 Million Novo Nordisk - ADR shares worth $1.7 Billion. It makes up 2.33% of their stock portfolio and is their biggest holding. The first Novo Nordisk - ADR trade was made in Q2 2013. Since then Jim Simons bought shares nineteen more times and sold shares on twenty occasions. The stake costed the investor $491 Million, netting the investor a gain of 246% so far.