Jim Simons acquired 8.19 Million Novo Nordisk shares worth $907 Million. That's 1.31% of their equity portfolio (2nd largest holding). The first Novo Nordisk trade was made in Q2 2013. Since then Jim Simons bought shares nineteen more times and sold shares on 26 occasions. The stake costed the investor $372 Million, netting the investor a gain of 144% so far.