Jim Simons acquired 16.2 Million Novo Nordisk - ADR shares worth $1.57 Billion. It makes up 2.56% of their stock portfolio and is their biggest holding. The first Novo Nordisk - ADR trade was made in Q2 2013. Since then Jim Simons bought shares nineteen more times and sold shares on 22 occasions. The stake costed the investor $737 Million, netting the investor a gain of 113% so far.