Jim Simons acquired 17.5 Million Novo Nordisk - ADR shares worth $1.86 Billion. It makes up 1.98% of their stock portfolio and is their biggest holding. The first Novo Nordisk - ADR trade was made in Q2 2013. Since then Jim Simons bought shares nineteen more times and sold shares on seventeen occasions. The stake costed the investor $796 Million, netting the investor a gain of 134% so far.