Jim Simons acquired 6.82 Million Novo Nordisk shares worth $475 Million. That's 0.67% of their equity portfolio (16th largest holding). The first Novo Nordisk trade was made in Q2 2013. Since then Jim Simons bought shares twenty more times and sold shares on 27 occasions. The stake costed the investor $310 Million, netting the investor a gain of 53% so far.