Jim Simons acquired 8.31 Million Novo Nordisk shares worth $539 Million. That's 0.83% of their equity portfolio (9th largest holding). The first Novo Nordisk trade was made in Q2 2013. Since then Jim Simons bought shares twenty more times and sold shares on 26 occasions. The stake costed the investor $378 Million, netting the investor a gain of 42% so far.