Jim Simons's position in Madrigal Pharmaceuticals is currently worth $15.1 Million. That's 0.02% of their equity portfolio (710th largest holding). The first Madrigal Pharmaceuticals trade was made in Q3 2016. Since then Jim Simons bought shares twelve more times and sold shares on eight occasions. The investor's estimated purchase price is $18.2 Million, resulting in a loss of 17%.