Jim Simons's position in Madrigal Pharmaceuticals is currently worth $48.2 Million. That's 0.07% of their equity portfolio (311th largest holding). The first Madrigal Pharmaceuticals trade was made in Q3 2016. Since then Jim Simons bought shares fourteen more times and sold shares on nine occasions. The stake costed the investor $44.3 Million, netting the investor a gain of 8.7% so far.