Jim Simons's position in Ionis Pharmaceuticals is currently worth $5.33 Million. That's 0.01% of their equity portfolio (1410th largest holding). The first Ionis Pharmaceuticals trade was made in Q4 2015. Since then Jim Simons bought shares ten more times and sold shares on twelve occasions. The investor's estimated purchase price is $8.03 Million, resulting in a loss of 34%.