Jim Simons's position in Horizon Therapeutics Plc is currently worth $335 Million. That's 0.44% of their equity portfolio (30th largest holding). The investor owns 1.46% of the outstanding Horizon Therapeutics Plc stock. The first Horizon Therapeutics Plc trade was made in Q2 2019. Since then Jim Simons bought shares five more times and sold shares on ten occasions. The stake costed the investor $129 Million, netting the investor a gain of 160% so far.