Jim Simons's position in Exelixis is currently worth $375 Million. That's 0.51% of their equity portfolio (28th largest holding). The investor owns 5.48% of the outstanding Exelixis stock. The first Exelixis trade was made in Q2 2014. Since then Jim Simons bought shares seventeen more times and sold shares on twelve occasions. The stake costed the investor $338 Million, netting the investor a gain of 11% so far.