Jim Simons's position in Exelixis is currently worth $370 Million. That's 0.56% of their equity portfolio (20th largest holding). The investor owns 5.43% of the outstanding Exelixis stock. The first Exelixis trade was made in Q2 2014. Since then Jim Simons bought shares 21 more times and sold shares on fifteen occasions. The stake costed the investor $313 Million, netting the investor a gain of 18% so far.