Jim Simons's position in Exelixis is currently worth $550 Million. That's 0.79% of their equity portfolio (9th largest holding). The investor owns 5.38% of the outstanding Exelixis stock. The first Exelixis trade was made in Q2 2014. Since then Jim Simons bought shares 23 more times and sold shares on sixteen occasions. The stake costed the investor $309 Million, netting the investor a gain of 78% so far.