Jim Simons's position in Exelixis is currently worth $721M. That's 0.99% of their equity portfolio (10th largest holding). The investor owns 5.68% of the outstanding Exelixis stock. The first Exelixis trade was made in Q2 2014. Since then Jim Simons bought shares 24 more times and sold shares on 21 occasions. The stake costed the investor $286M, netting the investor a gain of 152% so far.