Jim Simons's position in Exelixis is currently worth $638 Million. That's 0.95% of their equity portfolio (6th largest holding). The investor owns 5.44% of the outstanding Exelixis stock. The first Exelixis trade was made in Q2 2014. Since then Jim Simons bought shares 23 more times and sold shares on eighteen occasions. The stake costed the investor $298 Million, netting the investor a gain of 114% so far.