Alnylam Pharmaceuticals Inc

Alnylam Pharmaceuticals Inc

ALNY

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Market Cap$40.32B
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Compare to Similar Companies

P/E RatioDividendsReturn on EquityPrice-to-SalesDebt-to-Equity
Alnylam Pharmaceuticals IncAlnylam Pharmaceuticals Inc69.5-54%9.11.2

Earnings Call Q1 2026

April 30, 2026 - AI Summary

Q1 2026 results—major growth milestone (good): - Net product revenues: $1.036B ( +121% YoY and +4% vs Q4 2025 ). - TTR franchise: $910M net revenues (+153% YoY, +6% vs Q4), with U.S. TTR +230% YoY and international TTR -$7M vs Q4 (mostly Germany pricing adjustment) but +35% YoY. - Rare disease: $126M net revenues (+15% YoY), offset by higher gross-to-net deductions.
AMVUTTRA launch momentum + outlook (good, with some headwinds): - Yvonne/Tolga emphasize continued confidence in 2026 TTR revenue guidance (company reiterates full-year guidance). - U.S. execution: Adherence >90%, broad access, most patients with ~0 out-of-pocket, and physician pull-through strong. - Next-phase U.S. focus (growth drivers): (1) prescriber base expansion (already 1,200+ unique new U.S. prescribers since last March), (2) sustained category growth via AI-enabled diagnosis partnerships (e.g., Viz.ai, AHA initiative), (3) durable adherence/persistence. - Q1 “headwind” mechanics: Q1 results were described as largely demand-driven, but impacted by U.S. selling-week/calendar effects and insurance reauthorization timing. Gross-to-net/pricing effects offset some inventory benefits.
International pricing/reimbursement—Germany adjustment (bad/pressure, but manageable): - International TTR revenue slightly down vs Q4 mainly due to previously announced updated pricing in Germany post-ATTR-CM launch. - Offsetting positive forces: Japan strength (CM launch on track) and improved balance across international markets. - Management indicated ex-U.S. pricing dynamics generally remain a factor as more countries launch CM and may require price adjustments (potential knock-on effects to PN), but progress has been better than expected.

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$418.00

Target Price by Analysts

42.9% upsideAlnylam Pharmaceuticals Target Price DetailsTarget Price
$160.69

Current Fair Value

45.1% downside

Overvalued by 45.1% based on the discounted cash flow analysis.

Share Statistics

Market cap$40.32 Billion
Enterprise Value$39.88 Billion
Dividend Yield$- (-)
Earnings per Share$2.39
Beta0.3
Outstanding Shares132,893,000

Return

Return on Equity53.68%ROE
Return on Assets11.25%
Return on Invested Capital14.58%

Valuation & Multiples

P/E Ratio69.53P/E Ratio
PEG-15.17PEG
Price to Sales9.14Price to Sales
Price to Book Ratio36.57Price to Book Ratio
Enterprise Value to Revenue9.3
Enterprise Value to EBIT72.35
Enterprise Value to Net Income69
Total Debt to Enterprise0.03
Debt to Equity1.19Debt to Equity

Revenue Sources

No data

Insider Trades

Last Earnings Call

Report Date
May 7, 2026
EPS Estimate
$1.50
Average shareholder expectation
Revenue Estimate
$1.12 B
Average shareholder expectation

Next Earnings Call

Expected Date
July 30, 2026
EPS Estimate
$1.63
Average shareholder expectation
Revenue Estimate
$1.32 B
Average shareholder expectation

Institutional Put/Call Ratio

Market sentiment based on institutional option activity.

Put/Call Ratio0.4385 23.36%
Total Calls1,296,588 24.32%
Total Puts568,500 50.63%

Institutional Ownership

Holdings and activity of institutional investors.

Ownership %97.23% 1.47%
Total Invested$42.44B 17.59%
Investors Holding815 76.00%

ESG Score

No data

About Alnylam Pharmaceuticals Inc

CEO: John Maraganore

Relevant Senate Committees

Finance

As the most powerful economic committee, it controls taxation (affecting Alnylam's profitability), trade policy (impacting global supply chains and market access), and critically, entitlement spending, including Medicare pricing and policies, which are major determinants of pharmaceutical revenue.

Appropriations

This committee directly allocates discretionary federal spending. Its subcommittees determine the specific funding levels for crucial agencies like the FDA, NIH, CMS (Medicare/Medicaid), and VA, profoundly impacting the regulatory environment, research funding, and market access for Alnylam's products.

Health, Education, Labor, and Pensions

This committee directly regulates the FDA, which is responsible for drug approval, and the NIH, which funds biomedical research. These functions are absolutely critical to Alnylam's product development, market entry, and long-term pipeline success.

Judiciary

Intellectual property laws (patents) are foundational to the pharmaceutical industry's business model. This committee's oversight of the DOJ, antitrust enforcement, and IP directly impacts Alnylam's ability to protect its innovations and navigate market competition.