Tweedy Browne acquired 2.28M Ionis Pharmaceuticals shares worth $173M. That's 13.30% of their entire equity portfolio (2nd largest holding). The investor owns 1.41% of the outstanding Ionis Pharmaceuticals stock. The first Ionis Pharmaceuticals trade was made in Q1 2022. Since then Tweedy Browne bought shares two more times and sold shares on eleven occasions. The stake costed the investor $79.2M, netting the investor a gain of 118% so far.