Tweedy Browne acquired 2.98 Million Ionis Pharmaceuticals shares worth $119 Million. That's 10.55% of their entire equity portfolio (3rd largest holding). The investor owns 1.99% of the outstanding Ionis Pharmaceuticals stock. The first Ionis Pharmaceuticals trade was made in Q1 2022. Since then Tweedy Browne bought shares one more times and sold shares on eight occasions. The stake costed the investor $104 Million, netting the investor a gain of 14% so far.