Jim Simons's position in United Therapeutics is currently worth $590 Million. That's 0.95% of their equity portfolio (7th largest holding). The investor owns 4.89% of the outstanding United Therapeutics stock. The first United Therapeutics trade was made in Q2 2013. Since then Jim Simons bought shares 22 more times and sold shares on 21 occasions. The stake costed the investor $249 Million, netting the investor a gain of 137% so far.