Jim Simons acquired 10.8 Million Novo Nordisk shares worth $1.42 Billion. It makes up 2.29% of their stock portfolio and is their biggest holding. The first Novo Nordisk trade was made in Q2 2013. Since then Jim Simons bought shares nineteen more times and sold shares on 24 occasions. The stake costed the investor $490 Million, netting the investor a gain of 190% so far.